Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The Global Obesity Epidemic
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Investors are divided as to whether the anticipated rate increase by the US Federal Reserve tomorrow has already played out, or will intensify stress for indebted companies and economies.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Lawrence Yun, the trade group's chief economist, expects the average 30-year fixed-rate mortgage to hit 5.5% at year-end, up from 4.5% late last year and 3.5% in the first half of 2013. That's a sharp runup in a short period of time, one that could harm affordability and spook even more buyers.
While not a low rating when compared to the other four dramas, it was still criticized by many audience members.
"Based on experience from previous years, the number of applicants could sharply increase as the application window closes, especially during the last three days of application," an unidentified official with the Ministry of Human Resource and Social Security said on the ministry's website.
Trends and targets in antiviral phototherapy
When it’s time to buy a new car, you have 36 brands to choose from. Each automotive brand has something to offer, but not every brand is right for every buyer. Some brands excel at making performance cars, others focus on making family-friendly crossovers or specialize in luxury cars.
Historical and fictional films each have their own strengths when it comes to storytelling. Every now and then, though, movies pop up that don't quite fit into either category. The stories are wildly unrealistic, but they carry an inkling of truth between their pages. While these are some of the most interesting films out there, viewers often don't even know that what they're watching really happened. Well, wonder no more! Keep reading to learn about some of Hollywood's zanier scripts that took their inspiration from good old-fashioned real-life drama.
Yes. In 2018 President Trump will deliver on some of his protectionist campaign rhetoric by taking punitive actions against China. The most likely triggers for action will be official reports that the Trump administration has commissioned into China’s alleged theft of intellectual property, and its subsidised production of steel and aluminium. The president, spurred on by his trade team, is likely to order retaliatory measures, including tariffs. Whether that marks the first shot in a trade war will depend on how China reacts. A Chinese decision to impose retaliatory tariffs, or to take America to the World Trade Organization, will signal the opening of hostilities.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Burgeoning crude supply is liable to drive prices lower in 2014 after a run of years when emerging markets supported demand, as shifting dynamics continue to change the oil landscape.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
I'm only a child yet I know we are all part of a family, five billion strong, in fact, 30 million species strong and we all share the same air, water and soil -- borders and governments will never change that. 我只是一个小孩，但我知道我们都是一个大家庭的成员，超过60亿人的大家庭，以及超过三千万物种的大家庭，政府和国界永远都无法改变这个事实。
今日，麦高恩在杂志Sunday Times Magazine上对性侵维权运动做出不雅评论，头一天布雷特·卡瓦诺法官刚在最高法院中宣誓就职，并于当天否认了性侵控告。
ACE2 as a potential therapeutic target for pandemic COVID-19
"He (Premier Wen) underlined that China effectively countered the severe impact of the global financial crisis and has maintained steady and fast economic development. This allowed China to become the second-largest economy, almost doubling its GDP in five years."
“温家宝总理强调指出，中国有效应对了全球金融危机的严重影响，经济保持稳定快速增长。因此中国成为全球第二大经济体，在五年内GDP几乎翻番。”Luis Schmidt Montes, Chilean ambassador
Diagnostic technologies for COVID-19: a review
会。梅亚德是执政党革命制度党(PRI)的候选人。他主要的竞争对手是强硬的左翼领导人安德烈斯曼努埃尔洛佩斯奥夫拉多尔(Andrés Manuel López Obrador)——可以感召人群的激情演说家。梅亚德需要克服很多问题：在去年1月一夜间把油价上调20%、引发通胀飙升后，他必须说服选民自己仍然是可以信任的。他还必须证明自己是个有主见的人，而不仅仅是这届不受欢迎的政府的傀儡——在遏制猖獗的腐败和犯罪行为方面，这届政府极为失败。但是凭借强大的PRI拉票机器，他可能势不可挡。在墨西哥只有一轮选举的体制下，30%的选票可能就足以让他当选总统了。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Morgan Slain, CEO of SplashData said: "Seeing passwords like 'adobe123' and 'photoshop' on this list offers a good reminder not to base your password on the name of the website or application you are accessing.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Company: Binary Group
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Colliding Neutron Stars
10.Be Dedicated and balanced
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In 2017, his 14th season in the league, LeBron James averaged a career high in assists and rebounds. In the first two months of 2017-18, he's averaging a career high in 3-point percentage, but that's been talked about and dissected; it's been written about extensively.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
The below are 5 companies that stand out from the rest and are startups to watch in 2014.
Antiviral drug discovery: broad-spectrum drugs from nature
It was the age of wisdom, it was the age of foolishness…
Influenza neuraminidase: A druggable target for natural products
Do you tend to hide your feelings from others?
We believe our initiative of mass entrepreneurship and innovation is a response to the call of our time, the government self-targeted reform of streamlining administration and delegating power is also to boost this public enthusiasm for business start-ups and making innovations.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The number of moviegoers in 2016 reached 1.37 billion, an increase of nearly 8.9 percent year-on-year.
"Investing in innovation is critical to raising long-term economic growth," said WIPO Director General Francis Gurry. "In this current economic climate, uncovering new sources of growth and leveraging the opportunities raised by global innovation are priorities for all stakeholders."
The role of biosensors in the detection of emerging infectious diseases
Doing more to unleash the potential of domestic demand
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Hartz started Eventbrite, an online ticketing platform, with her now-husband Kevin in 2006. Since its founding, the company has raised $140 million from firms like Sequoia Capital and Tiger Global Management and reached $2 billion in gross ticket sales this September. Entrepreneurship forced Hartz to appreciate candid and collaborative conversations. "I had to learn how to ask for help," she says. "Everyone always thinks it's brave to go out alone, but I think it's even braver to put yourself out there in front of others, and to figure out how to work together."
The low reading was driven by a fall in the production component, whereas the forward-looking new orders component increased for a sixth straight month.
Despite the promise of downloadable courses, teaching for officially recognised qualifications continues to be a classroom-based activity undertaken in the real world. Start-ups have taken the attitude that if they cannot beat the universities and colleges at their own game with new methods of delivery, they should join them in partnerships. As a result, they have been busy getting examining boards to endorse their online courses so that they can count towards a bachelor’s or master’s qualification.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
“我们的初衷并不是要‘弃暗投明’—— 像他们在选举时说的那样。我们只是对大批新出现的动力引擎感到惊艳不已，” 《沃兹汽车世界》杂志（WardsAuto World）总编德鲁·温特（Drew Winter）表示，“昨天非常优秀的东西到了明天可能就不会再吸引人们的注意，因为发动机技术的改变是如此迅猛。”
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Truck wars: Awards aside, Ford’s aluminum pickup is hard to build and slow to sell, leaving an opening for Ram’s fast-rising 1500 while Nissan tries to forget the failure of its first full-size truck when it launches the second-generation Titan with the biggest of big rig styling. The industry’s biggest secret is revealed by veteran executive John Krafcik in Automotive News: In the
8) I am a closed kind of person 0 1 2 3 4
Inhibition of SARS coronavirus helicase by bismuth complexes
adj. 在 ... 之前，先，前，以前的
The bigger Tesla gets, the more complex its operations become. Since it sells directly to customers and eschews franchised dealers, it will have to develop a network of service centers to handle repairs on the cars it sells. Its unusually generous warranty, which obligates it to buy back used cars for 50% of their original base price after three years, could create a second channel of used Teslas. “Tesla will be eating a lot of three-year-old cars that aren’t as sexy or rare as they were a year ago,” wrote one Seeking Alpha blogger. ‘To me, it sounds like a potential mess.”
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Its Academic Ranking of World Universities is made up of six objective indicators, including the number of alumni and staff winning Nobel Prizes and Fields Medals, the number of highly-cited researchers, the number of articles published in the journals Nature and Science, the number of articles indexed in the "Science Citation Index", and their per capita performance.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
China's online game revenue in 2008 was CNY20.8 billion, accounting for about 27% global share, ahead of South Korea at 21% and slightly behind the U.S. at 29%, according to an earlier report by Shanghai-based market research firm iResearch. The firm also predicted that China is likely to surpass the U.S. to become the world's largest by the end of 2009.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
5.Create a Study Space
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Song of the year: "Over you," Miranda Lambert and Blake Shelton
最佳新人：Florida Georgia Line
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
The finest romance and the most acute anti-romance of the year, from some of the most rigorous intellects in American movies. The relationship between them is perhaps best summed up in this poem by William Blake, called “The Clod and the Pebble”:
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Wright is one of the most original figures of British Romantic painting, and this composition, held in the same private collection in Derbyshire since 1840, had an approachable low estimate of 100,000 because of condition issues and — not insignificantly — the fact that it was a charity donation to benefit Syrian refugees. As a result, at least three bidders pushed the price to 665,000 with fees.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Wuxi, in coastal Jiangsu province, retained the top spot for a second month with growth of 4.9 per cent,
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
In 2008, Janah talked to a call center worker from Dharavi, India, the largest slum in South Asia, while working as a consultant. The worker said there were millions of unemployed villagers as talented as he was. "I thought, 'What if outsourcing could generate a few dollars for billions of people, rather than billions of dollars for a wealthy few'" Janah says. She went on to launch Samasource, a tech platform that connects impoverished women and youth with large corporations like Google, LinkedIn, and Microsoft to complete digital projects. To date, the non-profit has helped over 16,000 people rise above the poverty line and it recently launched SamaUSA, a domestic program for low-income students living in San Francisco.
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
When it was set up in 2002, Teach First’s aim was to encourage more graduates to try teach-ing. Amid worries that the best brains in the country were being lured into the City of London, accountancy and law, the idea was to tap some of their brain power for state schools, in an attempt to tackle educational inequality.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资，把配置比重从两年前相对基准超配6%至8%调整至超配1%。
"All institutions in this list deserve to celebrate - being named one of the most international universities in the world is a sign of great potential, competitiveness and dynamism."
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
China’s investment in Europe and the US has reached record highs, despite the slowdown in the country’s domestic economy.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Another slowdown in food prices pulled Chinese inflation lower in October, according to the National Bureau of Statistics.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
都柏林大学学院(UCD)迈克尔?斯墨菲特商业研究生院(Michael Smurfit Graduate School of Business)的总体进步最大，排名攀升21位至第48名。北京大学(Peking University)光华管理学院(Guanghua School of Management)重回排行榜第38名，去年该院因学员调查反馈率低而未上榜。
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Best wishes for the holidays and happiness throughout the New Year.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Leading the pack of the best airlines for holiday travel is Hawaiian Airlines, followed by another Pacific Coast-focused carrier, Alaska Airlines. Conversely, the worst airline for holiday travel is New York-based JetBlue Airways, with ExpressJet, a regional carrier, coming in next to last, according to the FlightAware data.
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Choose the number next to each statement that best reflects your feelings.
China's economic performance in the past few years should suffice to put predictions of a hard landing to a full stop. China's economy will continue to enjoy medium-high growth and be upgraded to higher levels
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The malaise was not confined to those picking individual stock winners. Through December 1, aggregate hedge fund returns trailed the market to the point of farce. According to data compiled by Bloomberg, hedge funds were up an average of 2% on the year, just barely offering the coupon rate of a risk-free 10-year Treasury note. Over 1,000 funds are on track to close down in 2014, the worst year for liquidations since 2009.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
But shipments to other destinations fared far worse, particularly those to re-exporter Hong Kong, which saw the dollar value of exports from China contract 26.3 per cent year on year to $33.84bn. Shipments to EU countries also fell 4.7 per cent to $33.5bn, while those to Japan dropped 5.5 per cent to $11.27bn.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
The report shows double-eleven has become the biggest shopping event for the Chinese e-commerce industry, with Taobao, Tmall and JD.com leading the way.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
New Year should be a time of banked-up fines, the scent of flowers and wine, good talk, good memories and loyalties renewed. But if all else is lacking - love will do.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Beijing is banning Chinese tour groups from visiting South Korea, the latest retaliation against the planned Korean deployment of the US-built Thaad missile shield, according to two people with knowledge of the plans.
Anti-HIV drug repurposing against SARS-CoV-2
TWO Americans were awarded the Nobel economics prize yesterday for studies on the matchmaking taking place when doctors are coupled up with hospitals, students with schools and human organs with transplant recipients.
Length-scale dependence of protein hydration-shell density
Federica Mogherini, the EU’s foreign policy chief, and Johannes Hahn, the bloc’s enlargement commissioner, have also weighed in, criticising Mr Erdogan’s proposed constitutional changes and his recent rhetoric.
在开放课程排行榜顶端，赛德商学院(Sa?d Business School)排名上升幅度最大，跃升5位至第4名。这是这所位于牛津大学(University of Oxford)的商学院首次进入前五。赛德商学院在所有10项受学员评分影响的指标上的排名都有所提升。
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The fruit is placed into the mold when it's young and undeveloped.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
About this collection
The actress who kick-started the exposure of Hollywood moguls who allegedly exploited positions of power to abuse women has branded #MeToo campaigners against sex attackers 'losers'.